| Gene Symbol | MSH2 |
| Full Name | MutS Homolog 2 |
| Aliases | Page for MSH2 Protein |
| Function | MSH2 is essential for the DNA mismatch repair system: |
| Primary Expression | all brain cell types: - Neurons: High basal expression, constitutive MMR activity - Glia: Lower expression than neurons - |
| Subcellular Localization | </th><td>Nucleus</td></tr> |
| Molecular Weight | 104.7 kDa |
| Ensembl ID | ENSG00000116675 |
| GeneCards | MSH2 |
| Human Protein Atlas | MSH2 |
| DNA binding domain | Mismatch recognition |
| ATPase domain | ABC ATPase fold for conformational changes |
| MSH6/MSH3 interaction domain | Heterodimer formation |
| MutSα | MSH2-MSH6 heterodimer (recognizes base-base mismatches, 1-2 bp indels) |
| MutSβ | MSH2-MSH3 heterodimer (recognizes larger indels up to 10 bp) |
| Associated Diseases | Als, Cancer, Colorectal Cancer, Gastric Cancer |
| Interactions | LIG1, MLH1, MSH3, MSH6, PMS2 |
| KG Connections | 58 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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