| Gene Symbol | MDA5 |
| Aliases | MDA5PROTEIN |
| Function | Mda5 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Subcellular Localization | to Cytoplasm and plays a significant role in the pathogenesis of [Alzheimer's Di |
| UniProt ID | https://www.uniprot.org/uniprot/Q9QZF5 |
| GeneCards | MDA5 |
| Human Protein Atlas | MDA5 |
| PAMP recognition | Binds long dsRNA (>1 kb in length) |
| Viral specificity | Primarily detects picornaviruses, rotaviruses, noroviruses |
| Signal transduction | Activates MAVS (mitochondrial antiviral signaling protein) |
| Type I IFN induction | Triggers production of interferon-alpha/beta |
| C-terminal domain (CTD) | RNA binding |
| Helicase domain | ATP-dependent RNA unwinding |
| N-terminal CARD domains | Signal transduction via MAVS |
| Databases | GeneCardsNCBI GeneHPASTRING |
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