| Gene Symbol | MBL2PROTEIN |
| Function | is a key component of the innate immune system and a member of the collectin family of proteins. |
| Subcellular Localization | </b></td><td>Plasma, secreted</td></tr> |
| Molecular Weight | 26 kDa |
| GeneCards | MBL2PROTEIN |
| Human Protein Atlas | MBL2PROTEIN |
| Collagen-like regions | Triple helical domains that mediate trimerization |
| C-type lectin domains | Carbohydrate recognition domains (CRDs) that bind to mannose, N-acetylglucosamine, and fucose residues on pathogen surfaces |
| Neck regions | Alpha-helical segments that facilitate oligomerization |
| N-terminal cysteine-rich regions | Involved in disulfide bond formation |
| Peripheral immune activation | Circulating MBL2 can activate the complement system, leading to systemic inflammation that propagates to the central nervous system |
| Blood-brain barrier (BBB) modulation | MBL2 and complement activation products can compromise BBB integrity, allowing peripheral immune cells to enter the brain |
| Microglial activation | The complement pathway contributes to neuroinflammation in PD |
| Amyloid-β clearance | Some studies suggest MBL2 may aid in clearing amyloid-beta plaques through complement-mediated phagocytosis |
| Synaptic pruning | Excessive complement activation driven by MBL2 may contribute to synaptic loss in AD |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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