| Gene Symbol | Methyl-CpG Binding Domain Protein 3 |
| Aliases | Page for MBD3 Gene, Page for MBD3 Protein |
| Chromosome | 19p13.3 |
| Function | MBD3 is a core component of the NuRD complex, which possesses both chromatin remodeling ATPase (CHD4/Mi-2) and histone deacetylase (HDAC1/2) activities. |
| UniProt ID | Q9UBB4 |
| NCBI Gene ID | 53615 |
| Ensembl ID | ENSG00000071655 |
| OMIM | 157574 |
| Transcription Repression Regions | Multiple repression domains throughout MBD3 enable it to recruit and assemble functional NuRD complexes at specific genomic loci. |
| C-terminal Tail | The C-terminus contains regulatory motifs that control MBD3's activity and interactions with transcription factors and co-activators. |
| Neurogenesis | MBD3 controls the transition from neural progenitor cells to differentiated neurons by repressing progenitor-specific genes while allowing neuronal gene expression |
| Cortical Development | Regulates genes important for cortical layering and neuronal migration |
| Synaptogenesis | Controls expression of synaptic proteins necessary for proper synapse formation |
| Brain Region-Specific Patterns | Contributes to region-specific gene expression in hippocampus, cortex, and other brain areas |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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