| Gene Symbol | KIR23 |
| Full Name | Kir2.3 (Inward Rectifier Potassium Channel 2.3) |
| Protein Family | Inward rectifier potassium channel (Kir2.x) |
| Protein Type | Channel |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | the plasma membrane, with enrichment in postsynaptic densities |
| Molecular Weight | ~48 kDa |
| UniProt ID | P48745 |
| GeneCards | KIR23 |
| Human Protein Atlas | KIR23 |
| Two transmembrane domains | M1 and M2 helices that span the lipid bilayer |
| P-loop region | Forms the selectivity filter with the characteristic GYG motif that confers K+ selectivity |
| N-terminus and C-terminus | Cytoplasmic domains that regulate channel activity through interactions with PIP2 and polyamines |
| Polyamine binding site | Located in the cytoplasmic pore, responsible for strong inward rectification |
| PIP2 binding site | Phosphatidylinositol 4,5-bisphosphate is required for channel activation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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