| Gene Symbol | KIR21PROTEIN |
| Full Name | Kir2.1 |
| Protein Type | Protein |
| Function | is a member of the inward rectifier potassium channel family (Kir2. |
| Primary Expression | cardiac tissue and skeletal muscle - PIP₂ Dependence: The essential role of PIP₂ creates complexity in modulating channel activity - Blood-Brain |
| UniProt ID | Search UniProt |
| GeneCards | KIR21PROTEIN |
| Human Protein Atlas | KIR21PROTEIN |
| Resting Membrane Potential | Kir2.1 is the major conductance determining the resting membrane potential in many neuron types, typically maintaining around -70 mV |
| Repolarization | These channels contribute to the final repolarization phase of action potentials |
| Excitability Control | By setting the resting potential, Kir2.1 directly influences neuronal excitability and firing properties |
| Potassium Buffering | Kir2.1 helps regulate extracellular potassium levels during neuronal activity |
| Synaptic Integration | The channels influence synaptic integration by modulating input resistance |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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