| Gene Symbol | WASHC5 (formerly KIAA0196) |
| Full Name | WASH Complex Subunit 5 (Strumpellin) |
| Chromosome | 8q24.13 |
| Function | encodes a core component of the WASH complex that regulates endosomal protein sorting and recycling. |
| Subcellular Localization | ** | Endosomal membrane | |
| Amino Acids | 159 aa |
| UniProt ID | Q12768 |
| NCBI Gene ID | 9744 |
| Ensembl ID | ENSG00000104523 |
| OMIM | 610657 |
| WASH interaction domain | Mediates incorporation into the WASH pentameric complex |
| SWIP (WASHC4) | Direct binding partner; stabilizes strumpellin within the complex |
| CCDC53 (WASHC3) | Additional structural contacts |
| FAM21 (WASHC2) | Indirectly connected; FAM21 recruits WASH to retromer via VPS35 |
| WASH1 (WASHC1) | The actin nucleation-promoting factor |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!