| Gene Symbol | KCNK6PROTEIN |
| Protein Type | Channel |
| Function | is a member of the two-pore domain (K2P) potassium channel family. |
| Subcellular Localization | </strong></td><td>Cell membrane</td></tr> |
| Molecular Weight | 46 kDa |
| GeneCards | KCNK6PROTEIN |
| Human Protein Atlas | KCNK6PROTEIN |
| Four Transmembrane Segments | Unlike most potassium channels that have six transmembrane segments, K2P channels have only four. The pore domains are formed by the loops between transmembrane segments 1-2 and 3-4. |
| Two Pore Domains | Each subunit contains two pore domains (P1 and P2), and four subunits assemble to form a functional channel with four pore domains arranged around a central ion conduction pathway. |
| Dimeric Assembly | While four subunits are required for a functional channel, K2P channels form dimers, with each monomer contributing one pore domain to the overall channel structure. |
| Phosphorylation | Kinases can modulate KCNK6 activity |
| Glycosylation | Some K2P channels are glycosylated, affecting trafficking and function |
| Acetylation | May regulate channel activity |
| Action Potential Threshold | By setting the resting potential, KCNK6 influences the voltage threshold for action potential firing. |
| Firing Pattern | K2P channels modulate whether neurons fire tonically or exhibit burst firing patterns. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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