| Gene Symbol | HTR3APROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | areas involved in emesis, pain perception, mood, and cognition |
| Subcellular Localization | </th><td>Plasma Membrane (Ligand-Gated Ion Channel)</td></tr> |
| Amino Acids | 4477 aa |
| GeneCards | HTR3APROTEIN |
| Human Protein Atlas | HTR3APROTEIN |
| [Cortex](/brain-regions/cortex) | Layer-specific expression in pyramidal neurons and GABAergic interneurons |
| Amygdala | Expression in central and basolateral nuclei |
| Striatum | Moderate expression in medium spiny neurons |
| Brainstem | Expression in area postrema (chemoreceptor trigger zone) |
| Enteric Nervous System | High expression in submucosal and myenteric plexus |
| Ondansetron, Granisetron | Antiemetic agents blocking HTR3A |
| Potential Applications | Cognitive enhancement, pain management, mood disorders |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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