| Gene Symbol | GRP94 |
| Protein Type | Chaperone |
| Function | is a 90 kDa heat shock protein localized primarily to the endoplasmic reticulum (ER). |
| Primary Expression | astrocytes and oligodendrocytes - Synaptic terminals: Localized to presynaptic vesicles |
| Subcellular Localization | presynaptic vesicles and postsynaptic densities |
| Molecular Weight | 90 kDa |
| Pathways | Interaction |
| GeneCards | GRP94 |
| Human Protein Atlas | GRP94 |
| N-terminal Domain (amino acids 1-337) | ATP-binding pocket with unique regulatory features |
| Middle Domain (amino acids 338-600) | Client protein binding site with substrate specificity |
| C-terminal Domain (amino acids 601-803) | Dimerization domain and ER retrieval signal (KDEL) |
| Linker Region | Flexible connecting domain allowing conformational changes |
| Neurons | High expression in hippocampal CA1 pyramidal neurons, cortical layer 5 neurons, and cerebellar Purkinje cells |
| Glia | Expressed in astrocytes and oligodendrocytes |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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