| Gene Symbol | GIRK2 |
| Full Name | GIRK2 (G Protein-Activated Inward Rectifier Potassium Channel 2) |
| Aliases | G Protein-Activated Inward Rectifier Potassium Channel 2 |
| Protein Family | Inward rectifier potassium channel (Kir2.x) |
| Protein Type | Channel |
| Function | GIRK2 channels serve critical physiological roles |
| Primary Expression | dopaminergic neurons of the substantia nigra pars compacta (SNpc) |
| Subcellular Localization | Plasma membrane, , axon terminals |
| Molecular Weight | ~50 kDa |
| UniProt ID | P48051 |
| GeneCards | GIRK2 |
| Human Protein Atlas | GIRK2 |
| Four transmembrane domains | M1 and M2 helices form the channel pore |
| Selectivity filter | GYG motif confers K+ selective permeation |
| Cytoplasmic domains | N-terminus and C-terminus interact with G-protein beta-gamma subunits |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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