protein 604 words KG: GIGAXONINPROTEIN
Contents

Gigaxonin (GAN) Protein

🔬 Protein Info
Gene SymbolGIGAXONINPROTEIN
AliasesGIGAXONINPROTEIN
Chromosome16q24.1
N-terminal BAG domainMediates interaction with Hsp70 family chaperones
BACK domainRequired for E3 ubiquitin ligase activity
RING finger domainCatalytic domain for ubiquitin transfer
Severe Peripheral NeuropathyProgressive loss of motor and sensory function
Central Nervous System InvolvementDevelopmental delay, seizures, and intellectual disability
Distinctive Axonal MorphologyGiant axonal swellings due to neurofilament accumulation
Early-onsetSymptoms typically appear in early childhood
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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