protein 634 words KG: FTMTPROTEIN
Contents

Ferritin Mitochondrial (FTMT)

🔬 Protein Info
Gene SymbolFTMTPROTEIN
AliasesFTMTPROTEIN
Function### Monomer Structure
Subcellular Localization</td><td>Mitochondria (mitochondrial matrix)</td></tr>
Iron sequestrationStores excess iron in safe form
Ferroxidase activityConverts toxic Fe2+ to Fe3+
Iron availabilityRegulates iron for mitochondrial enzymes
Cellular iron balanceMaintains iron homeostasis
Prevents Fenton chemistryReduces hydroxyl radical formation
Lipid peroxidation preventionProtects membranes from ROS
DNA protectionReduces oxidative DNA damage
Iron-sulfur cluster synthesisProvides iron for Fe-S cluster assembly
Heme synthesisSupplies iron for heme biosynthesis
Respiratory chain functionProtects mitochondria from iron-induced damage
NeuroprotectionGuards neurons from iron-mediated toxicity
Synaptic functionSupports synaptic iron homeostasis
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (15)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (13)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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