| Gene Symbol | FLOTILLIN1 |
| Aliases | FLOTILLIN1PROTEIN |
| Chromosome | 6p21.3. |
| Function | Flotillin-1 (also known as FLOT1) is a 47 kDa integral membrane protein that localizes to lipid rafts, specialized microdomains in the plasma membrane enriched in cholesterol and sphingolipids. |
| GeneCards | FLOTILLIN1 |
| Human Protein Atlas | FLOTILLIN1 |
| SPFH Domain (N-terminal) | The N-terminal region (~80 amino acids) contains the SPFH domain, which is shared with other SPFH family members. This domain is critical for: |
| Flotillin Domain (C-terminal) | The C-terminal region (~300 amino acids) comprises the conserved "flotillin" domain of unknown function. This domain: |
| Insulin Signaling | Flotillin-1 regulates insulin receptor signaling and glucose uptake |
| MAPK/ERK Pathway | Controls cell proliferation and differentiation signals |
| EGFR Signaling | Modulates epidermal growth factor receptor function |
| Notch Signaling | Involved in developmental signaling |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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