| Gene Symbol | FERRITINLIGHTCHAINPROTEIN |
| Aliases | FERRITINLIGHTCHAINPROTEIN |
| Subcellular Localization | </td><td>Cytoplasm, lysosomes, mitochondria</td></tr> |
| Ions at subunit interfaces | FTL contributes hydrophobic residues at subunit interfaces that stabilize the cage |
| Iron nucleation site | FTL has residues (Glu56, Glu57) that promote iron phosphate mineral formation inside the cavity |
| C-terminal residues | Important for protein-protein interactions and targeting to specific cellular compartments |
| Cytosolic ferritin | Assembles in the cytoplasm as a stable 24-mer |
| Mitochondrial ferritin (FTMT) | A separate iron-storage protein in mitochondria, structurally similar but independently encoded |
| Targeting to lysosomes | Ferritin can be targeted for lysosomal degradation via ferritinophagy (NCOA4-mediated) |
| Prevents ferroptosis | Iron-dependent, lipid-peroxidation-driven cell death is suppressed by adequate ferritin stores [@song2020] |
| Antioxidant defense | By sequestering iron, ferritin prevents hydroxyl radical (·OH) formation via Fenton chemistry |
| Oligodendrocyte function | Myelin-producing oligodendrocytes have very high ferritin content — iron is required for myelin synthesis |
| Neuronal iron homeostasis | Neurons express ferritin in response to oxidative stress and iron loading |
| NCOA4 | The selective autophagy receptor that delivers ferritin to lysosomes |
| Iron release | Ferritinophagy releases stored iron, regulating the labile iron pool (LIP) |
| Ferroptosis regulation | NCOA4 knockdown prevents ferritinophagy and reduces ferroptosis sensitivity |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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