| Gene Symbol | FE65 |
| Aliases | Protein profile: FE65 Protein |
| Function | FE65 contains multiple protein-protein interaction domains including a WW domain and two phosphotyrosine-binding (PTB) domains, allowing it to function as a molecular scaffold linking APP to divers... |
| Subcellular Localization | Signals (NLS)**: FE65 can translocate to the nucleus where it functions as a tra |
| Molecular Weight | 60 kDa |
| Amino Acids | 580 aa |
| Pathways | oxidative stress response, cholesterol homeostasis, blood-brain barrier |
| GeneCards | FE65 |
| Human Protein Atlas | FE65 |
| WW Domain | Recognizes proline-rich sequences and participates in signaling complex formation |
| PTB Domains | Specifically bind the YENPTY motif at the APP C-terminus, enabling FE65-APP interaction |
| Nuclear Localization Signals (NLS) | FE65 can translocate to the nucleus where it functions as a transcription co-activator |
| Alpha-secretase processing | FE65 promotes non-amyloidogenic APP cleavage by alpha-secretase, producing sAPPα |
| Beta-secretase modulation | FE65 influences beta-secretase (BACE1) access to APP |
| Interactions | APP |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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