protein 2,772 words KG: FCGR2APROTEIN
Contents

FCGR2APROTEIN Protein

🔬 Protein Info
Gene SymbolFCGR2A
AliasesFCGR2APROTEIN
Chromosome1q23.3
Protein TypeReceptor
FunctionFCGR2A encodes a transmembrane glycoprotein receptor that binds the Fc region of IgG antibodies.
Subcellular LocalizationCell membrane (immune cells) and plays a significant role in the pathogenesis of [Alzheimer's Disease](/diseases/alzheim
GeneCardsFCGR2A
Human Protein AtlasFCGR2A
Associated Diseasesneurodegeneration
KG Connections1 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (20)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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