| Gene Symbol | EPN1 |
| Aliases | EPN1PROTEIN |
| Function | The ENTH domain adopts an structure that inserts into the inner leaflet of the plasma membrane, promoting clathrin coat invagination [@messa2014]. |
| Subcellular Localization | </b></td><td>Endosomes, clathrin-coated pits</td></tr> |
| Molecular Weight | 65 kDa |
| GeneCards | EPN1 |
| Human Protein Atlas | EPN1 |
| ENTH Domain (Epsin N-terminal Homology) | The N-terminal domain that binds phosphatidylinositol (PIs) and initiates membrane curvature |
| DPF Motifs | Multiple DPF (Asp-Pro-Phe) sequences that interact with clathrin coats |
| DPW Motifs | Additional clathrin-binding sequences |
| NRG Tripeptide | Critical for interaction with the ubiquitin-interacting motifs |
| UIM (Ubiquitin-Interacting Motif) | Recognizes ubiquitinated cargo proteins |
| PPXY Motif | Proline-rich region for WW domain interactions |
| Overexpression | EPN1 overexpression increases Aβ generation |
| Knockdown | EPN1 depletion reduces Aβ secretion |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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