| Gene Symbol | DOCK1PROTEIN |
| Full Name | Dedicator of Cytokinesis 1 Protein |
| Protein Family | DOCK family (DOCK-A subfamily) |
| Function | is a large guanine nucleotide exchange factor (GEF) that specifically activates Rac GTPases through its DHR-2 (Docker Homology Region 2) domain[@cote2005]. |
| Primary Expression | pyramidal and interneurons |
| Subcellular Localization | - **DHR-2 Domain (400-750)**: Catalytic GEF domain that activates Rac GTPases - |
| Molecular Weight | 215 kDa (1,864 amino acids) |
| Amino Acids | 864 aa |
| UniProt ID | Q8IU85 |
| GeneCards | DOCK1PROTEIN |
| Human Protein Atlas | DOCK1PROTEIN |
| DHR-1 Domain (1-400) | Phosphoinositide-binding region for membrane localization |
| DHR-2 Domain (400-750) | Catalytic GEF domain that activates Rac GTPases |
| SH3 Domains | Proline-rich regions for protein-protein interactions |
| C-terminal Region (750-1864) | Regulatory and scaffolding functions |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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