| Gene Symbol | DAT1PROTEIN |
| Function | is a protein that dat plays essential roles in:. |
| Primary Expression | Substantia nigra pars compacta, ventral tegmental area, striatum |
| Molecular Weight | ~79 kDa (705 amino acids) |
| Amino Acids | 705 aa |
| UniProt ID | Q01953 |
| GeneCards | DAT1PROTEIN |
| Human Protein Atlas | DAT1PROTEIN |
| DAT Downregulation | Progressive loss of DAT binding in PD patients observed via SPECT imaging (DaTscan) |
| Toxin-Induced PD | MPTP and 6-OHDA specifically target DAT to enter dopaminergic neurons |
| DAT Dysfunction | Reduced DAT activity may contribute to extracellular dopamine accumulation followed by progressive loss |
| Diagnostic Marker | DAT imaging is used to distinguish PD from non-degenerative parkinsonism |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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