| Gene Symbol | DARPP |
| Full Name | 32 Protein |
| Aliases | DARPP32PROTEIN |
| Function | Darpp 32 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| GeneCards | DARPP |
| Human Protein Atlas | DARPP |
| Thr-34 | Primary PKA phosphorylation site, converts DARPP-32 to a PP1 inhibitor |
| Thr-75 | PKA phosphorylation site that inhibits PKA itself |
| Ser-102 | Casein kinase 2 (CK2) phosphorylation site |
| Ser-130 | CDK5 phosphorylation site |
| D2 Receptor Pathway | D2 receptor activation reduces cAMP/PKA activity, leading to dephosphorylation of DARPP-32 and reduced PP1 inhibition. |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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