| Gene Symbol | CRMP2 |
| Aliases | Collapsin Response Mediator Protein 2 |
| Chromosome | 8p21.2 |
| Function | Collapsin Response Mediator Protein 2 (CRMP2), also known as Dihydropyrimidinase-like 2 (DPYSL2), is a critical cytoskeletal regulatory protein that plays essential roles in neuronal development, a... |
| Molecular Weight | 62 kDa |
| Amino Acids | 572 aa |
| Exons | 14 |
| GeneCards | CRMP2 |
| Human Protein Atlas | CRMP2 |
| N-terminal domain (residues 1-150) | Contains the dimerization interface and interacts with other CRMP family members |
| Central domain (residues 150-400) | Contains the core enzymatic fold with conserved residues |
| C-terminal domain (residues 400-572) | Mediates interactions with microtubules, actin, and signaling proteins |
| Phosphorylation | Multiple serine/threonine residues (Ser522, Thr514, Thr509, Thr507) are phosphorylated by various kinases |
| Sumoylation | Covalent modification by SUMO proteins affects protein stability and localization |
| Oxidation | Reactive oxygen species can modify CRMP2, affecting its function |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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