| Gene Symbol | COMPLEXIN |
| Full Name | 1 Protein (CPLX1) |
| Protein Family | Complexin family |
| Function | Synaptic vesicle fusion regulation |
| Primary Expression | excitatory neurons, essential for fast synchronous neurotransmitter release - CPLX2: Expressed in both excitatory and inhibit |
| Molecular Weight | 17 kDa |
| UniProt ID | Q9R0E5 (CPLX1), Q96A56 (CPLX2), Q8WV92 (CPLX3), Q7Z594 (CPLX4) |
| GeneCards | COMPLEXIN |
| Human Protein Atlas | COMPLEXIN |
| N-terminal Activating Segment (1-50 aa) | This region supports efficient calcium-triggered release. It contains the "激活" (activation) function that promotes fusion when calcium enters the presynaptic terminal. |
| Accessory Helix (50-75 aa) | This α-helix contributes to clamping of premature fusion by competing with synaptotagmin for SNARE complex binding. |
| Central Helix (75-110 aa) | The central region contains the high-affinity SNARE-binding helix that binds to assembled SNARE bundles. |
| C-terminal Segment (110-134 aa) | This region supports membrane association and spatial positioning at the active zone. |
| Cerebellar Circuits | Purkinje cell synapse timing |
| Hipppocampal Circuits | Memory and learning |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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