| Gene Symbol | CDK5R1 |
| Aliases | Cyclin-Dependent Kinase 5 Regulatory Subunit 1, p35/p25, CDK5 Activator 1 |
| Protein Family | CDK5 activator family |
| Protein Type | Kinase |
| Function | Instead, p35 (and its paralogue p39) serves as the exclusive activator in neurons[@tsai1994]. |
| Molecular Weight | 35 kDa |
| Amino Acids | 350 aa |
| UniProt ID | Q15078 |
| GeneCards | CDK5R1 |
| Human Protein Atlas | CDK5R1 |
| Neuronal migration | Controls radial migration of cortical neurons |
| Axon guidance | Regulates axonal outgrowth and pathfinding |
| Synaptogenesis | Essential for proper synapse formation and maturation |
| Cytoskeletal dynamics | Phosphorylates tau, MAP1B, and neurofilament proteins [@ohshima1996][@nikolic1996] |
| Long-term depression (LTD) | Controls NMDA receptor signaling |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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