| Gene Symbol | CDK5R1 |
| Aliases | Cyclin-Dependent Kinase 5 Regulatory Subunit 1, p35/p25, CDK5 Activator 1 |
| Protein Family | CDK5 activator family |
| Protein Type | Kinase |
| Function | Instead, p35 (and its paralogue p39) serves as the exclusive activator in neurons[@tsai1994]. |
| Subcellular Localization | ** Cytoplasm, membrane-associated (p35), cytosol (p25) |
| Molecular Weight | 35 kDa |
| Amino Acids | 350 aa |
| UniProt ID | Q15078 |
| GeneCards | CDK5R1 |
| Human Protein Atlas | CDK5R1 |
| Loss of myristoylation | p25 cannot associate with membranes |
| Increased stability | p25 has ~10x longer half-life than p35 (minutes vs hours) |
| Nuclear/cytosolic relocalization | CDK5-p25 accesses pathological substrates |
| Constitutive activation | No normal degradation mechanism |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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