| Gene Symbol | CATHEPSINAPROTEIN |
| Aliases | CATHEPSINAPROTEIN |
| Function | ### Lysosomal Carboxypeptidase Activity |
| Subcellular Localization | </strong></td><td>Lysosome, Secreted</td></tr> |
| Signal peptide (aa 1-20) | Targets the protein to the secretory pathway |
| Propeptide (aa 21-54) | Inhibits activity until activation in lysosomes |
| Catalytic domain (aa 55-380) | Contains the serine protease active site with catalytic triad (Ser195, Asp327, His69) |
| C-terminal domain (aa 381-479) | Contributes to enzyme stability and complex formation |
| Active site | Serine protease catalytic triad (Ser195, Asp327, His69) |
| Substrate specificity | Carboxypeptidase activity, preferring hydrophobic residues |
| pH optimum | Optimal activity in acidic lysosomal environment (pH 4.5-5.5) |
| N-linked glycosylation | Multiple glycosylation sites in the propeptide and catalytic domains |
| Proteolytic processing | Converted from zymogen to active enzyme in lysosomes |
| Phosphorylation | Some evidence for serine/threonine phosphorylation |
| Protein degradation | Cleaves C-terminal amino acids from peptide substrates |
| Glycoprotein processing | Removes terminal amino acids from glycoproteins |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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