SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
protein 897 words KG: C1QSUBUNITA
Contents

Complement C1q Subunit A Protein

🔬 Protein Info
Gene SymbolC1QSUBUNITA
Full NameComplement C1q Subunit A
Protein FamilyC1q family
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain by microglia and neurons and plays important roles in synaptic pruning, phagocytosis, and neuroinflammation
Molecular Weight26 kDa (subunit), 460 kDa (complex)
UniProt IDP02787
GeneCardsC1QSUBUNITA
Human Protein AtlasC1QSUBUNITA
Complement activationInitiates classical pathway
Synaptic pruningMediates synapse elimination
PhagocytosisPromotes microglial clearance
Disease associationsAlzheimer's disease, ALS, synaptic loss
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (11)

SASP-Mediated Complement Cascade Amplification
Score: 0.91Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78HDAC3-Selective Inhibition for Clock Reset
Score: 0.71

Related Analyses (13)

How does SPI1 transcriptionally regulate C1QA and C1QC expre
neuroinflammation · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

SciDEX — scidex.ai — Dashboard | Atlas

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)