| Gene Symbol | ATAXIN8 |
| Function | is a protein encoded by the ATXN8 gene. |
| Subcellular Localization | ** | Nucleus (intranuclear inclusions) | |
| Molecular Weight | 15 kDa |
| GeneCards | ATAXIN8 |
| Human Protein Atlas | ATAXIN8 |
| Polyglutamine tract | The central feature of Ataxin-8; normally 15-50 glutamine residues, expanded to 80-250 in SCA8 |
| Flanking sequences | Short N- and C-terminal sequences flanking the polyQ tract; these influence aggregation kinetics and toxicity |
| No known catalytic domain | Unlike Ataxin-3 (deubiquitinase) or Ataxin-1 (AXH domain), Ataxin-8 has no characterized enzymatic activity |
| Aggregation-prone | The expanded polyQ tract adopts β-sheet-rich amyloid-like conformations that drive protein aggregation |
| Polyglutamine (polyQ) | from the CAG reading frame (canonical Ataxin-8) |
| Polyalanine (polyA) | from the GCA reading frame; forms cytoplasmic aggregates |
| Polyserine (polyS) | from the AGC reading frame; accumulates preferentially in cerebellar white matter and is particularly toxic |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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