protein 1,791 words KG: ALSINPROTEIN
Contents

Alsin Protein

🔬 Protein Info
Gene SymbolALSINPROTEIN
Full NameAlsin
Protein TypeProtein
Functionis a Rab5-specific guanine nucleotide exchange factor (GEF) that plays critical roles in endosomal trafficking, neuronal survival, and axonal maintenance[@hadano2006].
Primary Expressionthe central nervous system, with highest levels in motor neurons, pyramidal neurons, and cerebellar Purkinje cells[@ito2007]
Subcellular Localizationto the cytoplasm and associated with endosomal membranes, where it regulates the
Molecular Weight210 kDa
Amino Acids847 aa
UniProt IDSearch UniProt
GeneCardsALSINPROTEIN
Human Protein AtlasALSINPROTEIN
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Glaucoma
KG Connections19 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (4)

R-Loop Resolution Enhancement Therapy
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (22)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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