protein 1,134 words KG: ADRA2CPROTEIN
Contents

Alpha-2C Adrenergic Receptor Protein

🔬 Protein Info
Gene SymbolADRA2C
Full NameAdrenoceptor Alpha 2C
AliasesADRA2CPROTEIN
Chromosome4p16.3
Primary Expressionthe central nervous system and peripheral tissues, playing crucial roles in regulating norepinephrine signaling, autonomic function, and stress respon
Amino Acids462 aa
PathwaysMAPK Pathway
UniProt ID[P21917](https://www.uniprot.org/uniprot/P21917)
Ensembl IDENSG00000141449
GeneCardsADRA2C
Human Protein AtlasADRA2C
N-terminal extracellular regionContains glycosylation sites
Transmembrane domains (TM1-TM7)Seven alpha-helices spanning the membrane
Intracellular loopsCouple to G proteins
C-terminal intracellular domainContains phosphorylation sites for desensitization
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (6)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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