| Prevalence | 1-2 per million annually |
| Creutzfeldt-Jakob Disease (CJD) | Sporadic, familial, iatrogenic, and variant forms |
| Fatal Insomnia (FI) | Familial and sporadic variants |
| Kuru | Historical epidemic in Papua New Guinea |
| Distinct incubation periods | Vary from weeks to years |
| Different neuropathology | Regional specificity varies |
| Species barriers | Transmission between species differs |
| Age | Typically 60-70 years |
| Progression | Rapid decline over weeks to months |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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