| Supplementary Motor Area (SMA) | Primary generator of learned motor sequences; loss leads to primitive reflex release |
| Premotor Cortex | Planning and coordination; degeneration disrupts inhibitory control |
| Prefrontal Cortex | Executive function and behavioral inhibition |
| Basal Ganglia | Modulation of motor output; dysfunction contributes to reflex release |
| Corpus Callosum | Interhemispheric coordination; damage may enhance reflex expression |
| Dopaminergic | Reduced inhibition from frontostriatal circuits |
| GABAergic | Loss of cortical inhibitory interneurons |
| Cholinergic | Frontal cholinergic deficiency affecting executive inhibition |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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