| Gene Symbol | POLD3 |
| Full Name | DNA Polymerase Delta Subunit 3 |
| Chromosome | 16q24.1 |
| Function | ### DNA Polymerase Delta Complex |
| Molecular Weight | 124 kDa |
| Amino Acids | 571 aa |
| UniProt ID | [Q9ZJM2](https://www.uniprot.org/uniprot/Q9ZJM2) |
| Ensembl ID | ENSG00000175482 |
| OMIM | 608412 |
| GeneCards | POLD3 |
| Human Protein Atlas | POLD3 |
| High metabolic demand | Neurons have high oxidative phosphorylation, producing reactive oxygen species (ROS) that cause oxidative DNA damage |
| Non-dividing state | Unlike other cell types, neurons cannot use cell division to dilute accumulated DNA damage |
| Long lifespan | Human neurons must maintain genome integrity for decades |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
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