| Gene Symbol | PLXNA4 |
| Aliases | PLXNA4PROTEIN |
| GeneCards | PLXNA4 |
| Human Protein Atlas | PLXNA4 |
| Extracellular Semaphorin-Binding Domain | High affinity binding for class 3 semaphorins, particularly Sema3A and Sema3B |
| Cysteine-Rich Repeats | Mediate receptor dimerization and ligand-induced activation |
| Single Transmembrane Helix | Anchors receptor in plasma membrane |
| Cytoplasmic GAP Domain | Possesses Ras GTPase-activating protein activity toward R-Ras, M-Ras, and Rap1 2 |
| Sympathetic Neurons | Regulates sympathetic chain formation |
| Neural Crest Cell Migration | Controls neural crest cell delamination and migration |
| Nociceptor Development | Guides developing pain-sensing neurons |
| Sensory Neuron Maintenance | Maintains adult sensory neuron integrity |
| Pain Modulation | Alters pain threshold through semaphorin signaling |
| Associated Diseases | Alzheimer's disease |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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