| Gene Symbol | PLXNA3 |
| Aliases | PLXNA3PROTEIN |
| Function | Plexin A3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| GeneCards | PLXNA3 |
| Human Protein Atlas | PLXNA3 |
| Extracellular Domain | Contains multiple semaphorin-binding domains (SBDs) and cysteine-rich repeats (CRs) that mediate ligand recognition and receptor clustering |
| Transmembrane Region | Single pass membrane-spanning helix that anchors the receptor in the plasma membrane |
| Cytoplasmic Domain | Contains a Ras GTPase-activating protein (GAP) domain that regulates downstream signaling through small GTPases including R-Ras, M-Ras, and Rap1 2 |
| Class 3 Semaphorins | Sema3A, Sema3B, Sema3C, Sema3F signals through Plexin A3 to cause growth cone collapse and axonal repulsion |
| Corticospinal Tract | Guides corticospinal motor axons during development |
| Olfactory System | Regulates olfactory bulb interneuron migration and circuit formation |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!