| Depression | Present in up to 50% of PDD patients[@aarsland2024] |
| Anxiety | Generalized anxiety and panic attacks |
| Apathy | Loss of motivation and interest |
| Visual Hallucinations | Often occur spontaneously or induced by medications |
| Delusions | Paranoid ideation and misinterpretations |
| Stage 1-2 | Lower brainstem and olfactory bulb (motor symptoms begin) |
| Stage 3-4 | Midbrain, including substantia nigra (full motor syndrome) |
| Stage 5-6 | Limbic system and neocortex (cognitive symptoms emerge) |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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