mechanism 2,366 words KG: ent-gene-58ffe46a
Contents

SYK Kinase in Microglial Activation and Alzheimer's Disease

🔬 Protein Info
Gene Symbolent-gene-58ffe46a
Active SYK> VAV/Rac -> cytoskeletal reorganization for particle engulfment
Suppressed SYK> NF-kappaB -> sustained inflammatory cytokine production
DAM1Early-stage microglia with increased SYK activity, enhanced phagocytic capacity
DAM2Late-stage microglia with suppressed SYK, dominated by inflammatory gene expression
KG Connections11 knowledge graph edges
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