mechanism 2,969 words KG: ent-gene-a6bc93bc
Contents

TNF Signaling Pathway in Neurodegeneration

🔬 Protein Info
Gene Symbolent-gene-a6bc93bc
Pro-inflammatory cytokinesIL-1β, IL-6, IL-8
ChemokinesCCL2, CXCL10
Acute phase proteinsC-reactive protein, serum amyloid A
Anti-apoptotic proteinsBcl-2, Bcl-xL, c-IAP1/2
Cell adhesion moleculesICAM-1, VCAM-1
KG Connections6 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (150)

Near-infrared light therapy stimulates COX4-dependent mitoch
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Epigenetic Memory Erasure via TET2 Activation
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PARP1 Inhibition Therapy
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Aquaporin-4 Polarization Rescue
Score: 0.73
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
← Prevpg 2/8Next →

Related Analyses (30)

Systemic immune profiling and peripheral immune contribution
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · completed
Why do systemic anti-inflammatory drugs fail in AD despite c
clinical neurology · completed
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Electroacupuncture ST37 treatment for DSS-induced colitis in
validation · proposed · Score: 0.95
Network pharmacology analysis of QTJD active compounds and p
exploratory · proposed · Score: 0.90
Acteoside treatment in LPS-induced SALI mouse model
validation · proposed · Score: 0.90
In vitro PANoptosis protection by LPT1 in hepatocytes
exploratory · proposed · Score: 0.80
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypotheses
China Neurodegeneration Epidemiology
disease · Pages share 139 hypotheses
Neuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (6 edges)

h-c1828e7264 targets ent-gene-a6bc93bc
ent-gene-a6bc93bc targeted_by h-c1828e7264
ent-gene-a6bc93bc data_in benchmark_ot_ad_answer_key:TNF
benchmark_ot_ad_answer_key:TNF data_in ent-gene-a6bc93bc
h-be723cd406 targets ent-gene-a6bc93bc
ent-gene-a6bc93bc targeted_by h-be723cd406

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