| Gene Symbol | ent-gene-d289a3d6 |
| Function | - Chronic oxidative stress: Excessive ROS overwhelms the Nrf2 system |
| Glutathione metabolism | GCLC, GCLM, GSR, GPx |
| Detoxification | NQO1, HMOX1 (HO-1), UGT1A1 |
| Proteostasis | SQSTM1 (p62), ALP genes |
| Mitochondrial function | PGC-1α (via NRF-1) |
| Drug metabolism | GST family members |
| Chronic oxidative stress | Excessive ROS overwhelms the Nrf2 system |
| Dopamine oxidation | L-DOPA therapy and endogenous dopamine oxidation generate quinones that deplete cellular antioxidants |
| Mitochondrial Complex I deficiency | A hallmark of sporadic PD reduces cellular energy and increases ROS |
| Neuroinflammation | Chronic microglial activation produces reactive nitrogen species that nitrosylate Nrf2 |
| p62/SQSTM1 | Nrf2 directly activates p62 transcription; p62 then competitively binds Keap1, creating a positive feedback loop |
| Mitophagy | Nrf2 target genes include parkin (PRKN) and FUNDC1 |
| Mitochondrial dynamics | Nrf2 influences fusion/fission balance through MFN2 regulation |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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