mechanism 2,962 words KG: ent-gene-75b41c33
Contents

Irisin (FNDC5) - Exercise-Induced Myokine for Neurodegeneration

🔬 Protein Info
Gene Symbolent-gene-75b41c33
Chromosome1p31.3
Skeletal musclePrimary source during exercise
Cardiac muscleMinor contribution
BrainLow levels of FNDC5 expression in neurons
PGC-1αMaster transcriptional coactivator controlling FNDC5 expression
Exercise intensityHigher intensity leads to greater induction
Muscle fiber typeMore pronounced in oxidative (type I) fibers
Circadian regulationDiurnal variation in FNDC5 expression
KG Connections3 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (140)

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Related Analyses (30)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
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neurodegeneration · archived
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Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
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s:** - Test tau spreading in AQP4 knockout vs wild-type mice
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s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Tau Co-Pathology in DLB Clinical Heterogeneity
clinical · proposed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypotheses
China Neurodegeneration Epidemiology
disease · Pages share 139 hypotheses
Neuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (3 edges)

ent-gene-75b41c33 data_in benchmark_ot_ad_answer_key:FNDC5
benchmark_ot_ad_answer_key:FNDC5 data_in ent-gene-75b41c33
24120943 elevated by ent-gene-75b41c33

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