| Gene Symbol | ent-gene-caf074c2 |
| Function | CBP is a histone acetyltransferase (HAT) and transcriptional coactivator |
| Normal function | Wild-type huntingtin sequesters REST in the cytoplasm, preventing REST from entering the nucleus |
| In HD | Mutant huntingtin loses this function, allowing REST to translocate to the nucleus |
| Consequence | Reduced histone acetylation and transcriptional silencing[@mcquaid2016] |
| Target genes | N-methyl-D-aspartate (NMDA) receptor subunits, synapsins, neurotrophic peptides |
| Interaction | mHTT binds to Sp1 and TAFII130 (TBP-associated factor) |
| Affected pathways | DNA repair genes, anti-apoptotic proteins |
| Nuclear accumulation | mHTT promotes p53 nuclear accumulation |
| Transcriptional shift | p53 shifts from pro-survival to pro-apoptotic gene targets |
| Sequestration | mHTT aggregates trap CBP, reducing its nuclear availability |
| Therapeutic target | HDAC inhibitors can partially restore CBP function |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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