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mechanism 2,037 words KG: ent-gene-8c4c3123
Contents

Exercise-BDNF-Mitochondrial Resilience Hypothesis in Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-8c4c3123
IrisinCleaved from FNDC5, crosses the blood-brain barrier, enhances hippocampal function[@martinez2022]
Cathepsin BReleased during endurance exercise, increases BDNF expression in the hippocampus
BDNFDirectly released from muscle cells in response to contraction, contributes to circulating levels[@cacciola2020]
LactateActs as a signaling molecule, enhances neuronal plasticity and memory formation[@yuan2023]
BAIBA (β-aminoisobutyric acid)Reduces inflammation and improves insulin sensitivity
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Vagal Afferent Microbial Signal Modulation
Score: 0.62Senescent Cell Mitochondrial DNA Release
Score: 0.74

Related Analyses (30)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (30)

Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecu
clinical · proposed · Score: 0.40AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-8c4c3123 data_in benchmark_ot_ad_answer_key:BDNF
benchmark_ot_ad_answer_key:BDNF data_in ent-gene-8c4c3123

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