| Gene Symbol | ent-gene-8c4c3123 |
| PI3K activation | p85 adaptor subunit binds phosphorylated Trk receptors |
| Akt phosphorylation | PDK1 and mTORC2 phosphorylate Akt at multiple sites |
| Pro-survival effects | Akt phosphorylates BAD, inhibits caspase-9, promotes protein synthesis |
| Neurodegeneration links | Impaired PI3K/Akt signaling contributes to neuronal death in AD and PD |
| Ras activation | Grb2/SOS complex recruitment activates Ras |
| MEK activation | Raf phosphorylates and activates MEK1/2 |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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