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mechanism 701 words KG: ent-prot-1332b5ae
Contents

GCase and Lysosomal Function in Parkinson's Disease

⚙ Mechanism Info
Nameent-prot-1332b5ae

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Related Hypotheses (37)

SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72Lysosomal Enzyme Trafficking Correction
Score: 0.71Lysosomal Calcium Channel Modulation Therapy
Score: 0.70Lysosomal Positioning Dynamics Modulation
Score: 0.69Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54Lysosomal Membrane Repair Enhancement
Score: 0.54The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.98Transcriptional Autophagy-Lysosome Coupling
Score: 0.92APOE-Dependent Autophagy Restoration
Score: 0.88Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Senescent Cell Mitochondrial DNA Release
Score: 0.74
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Related Analyses (2)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

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