| Prevalence | lvPPA accounts for approximately 30-40% of all PPA cases |
| Age of onset | Typically between 60-70 years, with a mean onset age of 67 years |
| Sex distribution | Slight female predominance in some studies |
| Progression | Disease progression typically leads to widespread cognitive impairment consistent with Alzheimer's disease over 8-14 years |
| Memory impairment | Episodic memory deficits often emerge early |
| Visuospatial deficits | May develop as disease progresses |
| Executive dysfunction | Variable involvement in later stages |
| Calculation difficulties | Particularly for complex arithmetic |
| Short-term memory deficits | Working memory impairment affecting sentence repetition |
| Left posterior superior temporal gyrus | Primary region of atrophy |
| Inferior parietal lobule | Including the supramarginal gyrus |
| Posterior cingulate | Variable involvement |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
No AI portrait yet
No comments yet. Be the first to comment!