| Age | The strongest risk factor; LATE is overwhelmingly a disease of advanced age |
| Female sex | Women appear to be at modestly higher risk |
| Genetic factors | Variants in TMEM106B, GRN (encoding progranulin, ABCC9, KCNMB2, and APOE, a nuclear RNA-binding protein that normally regulates mRNA splicing, stability, and transport. In LATE: |
| Cerebrovascular disease | Arteriolosclerosis, microinfarcts, and white matter changes |
| Lewy body pathology | [alpha-synuclein/proteins/alpha deposits may also co-occur |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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