| Gene Symbol | KIF21A |
| Full Name | Kinesin Family Member 21A |
| Protein Type | Gene |
| Function | KIF21A is a plus-end-directed kinesin that moves along microtubules |
| Primary Expression | neurons and plays critical roles in axonal and dendritic transport, contributing to synaptic function and neuronal viability |
| Amino Acids | 1640 aa |
| GeneCards | KIF21A |
| Human Protein Atlas | KIF21A |
| Motor Domain | KIF21A contains a motor domain that hydrolyzes ATP to generate force for movement along microtubules |
| Cargo Binding | The tail domain binds to various cargoes including vesicles, protein complexes, and organelles |
| Neuronal Specificity | KIF21A expression is enriched in neurons, particularly in axons and dendrites |
| Microtubule Tracking | KIF21A tracks along microtubule plus ends, facilitating long-range transport |
| Axonal Transport Defects | KIF21A dysfunction may contribute to axonal transport deficits observed in AD[@millecamps2013] |
| Amyloid Effects | Aβ oligomers disrupt kinesin-based transport, potentially affecting KIF21A function |
| [Tau](/proteins/tau) Pathology | Hyperphosphorylated tau disrupts microtubule integrity, impairing KIF21A-mediated transport |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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