| Progressive course | Symptoms worsen over months to years |
| Motor impairment | Spastic paraparesis affecting gait and balance |
| Autonomic dysfunction | Urinary urgency, incontinence, and constipation |
| No cure | Treatment focuses on symptom management and immunotherapy |
| Progressive spastic paraparesis | stiffness and weakness in both legs |
| Gait disturbance | difficulty walking, frequent tripping |
| Lower extremity spasticity | muscle rigidity, clonus |
| Urinary urgency and incontinence | bladder dysfunction |
| Constipation | bowel dysfunction |
| Lower back pain | often chronic |
| Paresthesias | tingling, numbness in legs |
| Impaired vibration sense | particularly in ankles |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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