| Gene Symbol | ent-gene-5d1a293a |
| Chromosome | 6p12 |
| NCBI Gene ID | 3362 |
| Morphology | hypocretin-secreting neuron (source: Cell Ontology) |
| Protein length | 460 amino acids |
| Molecular weight | ~52 kDa |
| G protein coupling | Gq, Gs - activates PLCβ and stimulates cAMP |
| N-terminal extracellular domain | orexin-A and orexin-B binding |
| Third intracellular loop | G protein coupling |
| C-terminal intracellular tail | phosphorylation sites |
| Orexin-A (hypocretin-1) | 33 amino acids, higher affinity for HCRTR2 |
| Orexin-B (hypocretin-2) | 28 amino acids, equal affinity for HCRTR1/HCRTR2 |
| Orexin-C | alternative splice product |
| Tuberomammillary nucleus (TMN) | histaminergic wake-promoting neurons |
| Perifornical area (PeF) | orexin neuron population |
| Lateral hypothalamus (LH) | orexin/hypocretin neurons |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
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