| Gene Symbol | ZRANB3 |
| Full Name | Zinc Finger RanBP2-Type Containing 3 |
| Chromosome | 2q14.3 |
| Function | is a DNA-dependent ATPase and endonuclease critical for the resolution of DNA replication stress and the maintenance of genome stability. |
| Subcellular Localization | to sites of replication stress [3] - **Genome Stability Maintenance**: Prevents |
| Ensembl ID | ENSG00000162738 |
| GeneCards | ZRANB3 |
| Human Protein Atlas | ZRANB3 |
| Replication Fork Remodeling | Reverses stalled replication forks by branch migration, converting damaged forks into structures amenable to repair |
| DNA Annealing Activity | Promotes strand annealing during DNA repair synthesis |
| Endonuclease Activity | Cleaves DNA structures during repair processing |
| PCNA Interaction | Recruits to stalled forks via PCNA interaction, ensuring proper localization to sites of replication stress [3] |
| Genome Stability Maintenance | Prevents chromosomal instability that can lead to cell death or transformation |
| [PCNA](/proteins/pcna-protein) | Sliding clamp that recruits ZRANB3 to stalled forks |
| [RAD51](/genes/rad51) | Recombinase involved in homologous recombination repair |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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